The Substance

2024 "Have you ever dreamt of a better version of yourself?"

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The Substance

7.2 | 2h21m | R | en | Drama

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

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7.2 | 2h21m | R | en | Drama , Horror , Science Fiction

Synopsis

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Cast

Demi Moore , Margaret Qualley , Dennis Quaid

Director

Krystell Morantin

Producted By

Working Title Films , Working Title Films

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Trailers

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Cast

Demi Moore

as Elisabeth

[2025] Emma and Bruce Willis: The Unexpected Journey – A Diane Sawyer Special [2025] The Tiger [2025] The Tiger [2025] The Tiger [2025] The Tiger [2025] The Tiger [2025] The Tiger [2025] St. Elmo's Fire [2025] Ghost

Margaret Qualley

as Sue

[2026] The Dog Stars [2025] Blue Moon [2025] Honey Don't! [2025] The Making of The Substance [2024] The Button [2024] The 66th Annual Grammy Awards [2024] Drive-Away Dolls [2024] Possessing Beauty: The Making of Poor Things [2024] The Substance

Dennis Quaid

as Harvey

[2026] I Can Only Imagine 2 [2025] Broke [2025] Sovereign [2025] Happy Face [2025] Twin Towers: Legacy [2025] The Making of The Substance [2024] The Long Game [2024] The Substance [2024] Reagan